In China, a meta-analysis reported the overall HIV seroconversion rate among serodiscordant couples in China to be 1.2 per 100 PYs. T2 - Dyadic processes of partner selection. serodiscordant couples from three cities in Australia (Sydney, Melbourne, and Brisbane), in Bangkok, Thailand, and in Rio de Janeiro, Brazil. Furthermore, studies recruiting a larger number of both HIV serodiscordant and HIV positive seroconcordant couples are needed to further test findings from this study. HIV/AIDS in children: a disaster in the making The Countdown to 2015 meeting earlier this year Using protection means that couples can have sex without passing HIV on. Couples with one person who is HIV-positive and one who is HIV-negative are sometimes called “serodiscordant” or “mixed serostatus”. Melo MG, Santos BR, De Cassia Lira R, et al. The PARTNER study was a prospective observational study that evaluated the risk of HIV transmission through condomless anal sex among serodiscordant men who have sex with men (MSM) couples when the HIV-positive partner was taking virally suppressive antiretroviral therapy (ART). The HPTN-052 … In China, a meta-analysis reported the overall HIV seroconversion rate among serodiscordant couples in China to be 1.2 per 100 PYs. No vertical transmission occurred. Genetic variations have been shown to be associated with HIV susceptibility and AIDS progression [ 2 , 3 ]. Background: Numerous prospective studies have demonstrated that HIV transmission is greatly reduced in heterosexual HIV serodiscordant couples when the HIV-positive partner (HPP) is receiving combination anti-retroviral therapy (cART) with undetectable viral load (UVL). Study Design: The study is a Phase III, two-arm, randomized, controlled, multi-center trial. HIV transmission rates within serodiscordant couples /partners are typically high, ranging from 3.7 to 19.0 per 100 person years (PYs) at risk. Abstract:Background: HIV transmission during pregnancy and breastfeeding among serodiscordant heterosexual couples represents an ongoing barrier to the elimination of vertical transmission of HIV-1 infection in Canada. The Partners Demonstration Project took place in Uganda and Kenya, and involved 1013 HIV-serodiscordant couples who were followed for 2 years. Methods/Design: The Opposites Attract Study is an observational prospective longitudinal cohort study of male homosexual serodiscordant partnerships running from 2012 to 2015 and conducted in clinics throughout Australia, Brazil and Thailand. Studies in heterosexual HIV serodiscordant couples have provided critical evidence on the role of HIV treatments and undetectable viral load in reducing the risk of HIV transmission. AU - Eaton, Lisa A. HIV Transmission Risk Among Serodiscordant Couples: PARTNER Study Findings. Therefore cohabiting serodiscordant couples (HIV infected individuals with uninfected partners of opposite sex) are at an especial high risk of transmission. ABSTRACTIntroduction:The use antiretroviral reduces the sexual transmission of HIV, expanding interventions for serodiscordant couples.Objective:This article aims to review the use of antiretroviral and other prevention interventions among serodiscordant couples and to analyze its use in Brazil.Methods:A retrospective review was performed through the MEDLINE … A randomized controlled trial Sibongile Mashaphua, Gail E. Wyattb, Muyu Zhangb, Thuli Mthiyanec, Honghu Liub and Exnevia Gomod risk of transmission from anal sex in homosexual male serodiscordant couples. Crucially, this effect evolved over time, with minimal protection from ART in the earlier phase of the study (2006–2008), and a strong preventive effect taking hold from 2009 to 2012. Serodiscordant couples face numerous issues not faced by seroconcordant couples, including decisions as to what level of sexual activity is comfortable for them, knowing that practicing safer sex reduces but does not eliminate the risk of transmission to the HIV-negative partner. Cite this: HIV Transmission Risk Among HIV Seroconcordant and Serodiscordant Couples: Dyadic Processes of Partner Selection - Medscape - Apr … Read online. Conclusion Despite concerted attempts to minimize HIV transmission during pregnancy and breastfeeding in our well-resourced setting, residual transmission risk remains due to non-suppressed viral load within many HIV-serodiscordant pregnant couples. There is very limited data on the risk of transmission from anal sex in homosexual male serodiscordant couples. Viral suppression and HIV transmission in serodiscordant male couples: an international, prospective, observational, cohort study Evidence on viral load and HIV transmission risk in HIV-serodiscordant male homosexual couples is limited to one published study. 2008;35(11):912-915.PubMed Google Scholar Crossref Men in these serodiscordant couples used a variety of strategies to reduce the risk of HIV transmission while having anal intercourse in their relationships. AbstractWith the planned scale-up of pre-exposure prophylaxis (PrEP) for HIV prevention among serodiscordant couples in resource-limited settings, gaining an understanding of what motivates serodiscordant couples to prevent HIV is critical. Sex Transm Dis. 6 HIV-positive partners received ART and HIV-negative partners received PrEP before and during their partners’ first 6 months of ART. Plos One 2009, 4; e5272:1-9 Guidance on couples HIV testing and counselling includ-ing antiretroviral therapy for treatment and prevention in serodiscordant couples: recommendations for a public health approach. Couples in whom transmission occurs (%) Treatment alone 100% condom use 80% condom use Combined treatment and 100% condom use Figure: Transmission risk over 100 sex acts in discordant male couple Derived with model in reference 4. Keywords:HIV, heterosexual transmission, vertical transmission, serodiscordant couple, prevention, pregnancy. A serodiscordant relationship is one in which one partner is HIV-positive and the other is HIV-negative. Clinical studies have demonstrated that effective ART profoundly reduces the risk for HIV transmission. Today’s post focuses on preventing HIV transmission in discordant couples, or “serodiscordant couples,” in which one member of the couple is HIV-positive and the other is not. There are a number of ways for serodiscordant couples to reduce the risk of HIV transmission to the uninfected partner. Likewise, unequal sample sizes found in this study reduce statistical power and, therefore, may yield more conservative estimates than what would be found if sample sizes were equal. It will also address the important benefits that condomless sex offers couples. One‐quarter of the couples practiced consistent condom use and just under half of the reported acts of anal intercourse were condom‐protected. This suggests that future programs that target serodiscordant couples could be a novel and effective means of preventing HIV-1 transmission … Only randomised controlled trials comparing transmission in HIV serodiscordant couples, where the infected (index) partner receives or does not receive antiretroviral drugs, can accurately estimate the effect of such treatment on infectivity. Background. We calculated transmission rates in couples reporting condomless anal intercourse (CLAI), when HIV-positive partners were virally suppressed, and daily pre-exposure prophylaxis (PrEP) was not used by HIV-negative partners. Introduction There are few data about the range of strategies used to prevent sexual HIV transmission within gay male serodiscordant couples. Download our HIV & mixed status couples fact sheet to find out more. RESEARCH LETTERS Research letters Transmission of HIV-1 and HLA-B allele-sharing within serodiscordant heterosexual Zambian couples M Tevfik Dorak, Jianming Tang, Ana Penman-Aguilar, Andrew O Westfall, Isaac Zulu, Elena S Lobashevsky, Nzali G Kancheya, Margaret M Schaen, Susan A Allen, Richard A Kaslow Factors that might increase risk of HIV-1 transmission include the present … HIV & mixed status couples fact sheet. This paper will review the evidence surrounding HIV transmission risk among serodifferent couples with and without the use of condoms and will highlight factors that increase or attenuate this risk.
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